Article

Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue

2023-04-28

Abstract excerpt

Single-cell transcriptional profiling reveals cell heterogeneity and clinically relevant traits in intra-operatively collected patient-derived tissue. However, the established approach to perform such analyses on freshly collected tissue constitutes an important limitation since it requires prospective collection and immediate processing. Therefore, the ability to perform single-cell RNA sequencing from archived t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30bf24a9-d2f6-55e7-b3da-982306104047
DOI: 10.1101/2023.04.25.538273

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissueDOI 10.1101/2023.04.25.538273Read

Deciphering Human Tumor Biology by Single-Cell Expression ProfilingSemantic proximity Read

Integrative single cell analysis to decode transcriptomic heterogeneity in pulmonary fibrosis across diverse pathologiesSemantic proximity Read

Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancerSemantic proximity Read

Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancerSemantic proximity Read

Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancerSemantic proximity Read

Signatures of malignant cells and novel therapeutic targets revealed by single‐cell sequencing in lung adenocarcinomaSemantic proximity Read

Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lungSemantic proximity Read

Beyond Histology: A Unified Transcriptomic Atlas Defines Lung Cancer Biologic States and SubtypesSemantic proximity Read

Decoding Cancer Biology One Cell at a TimeSemantic proximity Read

Evaluation of single-cell RNA profiling technologies using FFPE, fresh, and frozen ccRCC tumor specimensSemantic proximity Read

Routine FFPE sections support clinically compatible single-nucleus transcriptomics across six human cancer typesSemantic proximity Read

Versatile workflow for cell type–resolved transcriptional and epigenetic profiles from cryopreserved human lungSemantic proximity Read