Article
Autoimmune hepatitis, HLA and extended haplotypes.
Autoimmunity reviews - 1 Feb 2011
Oliveira Lea Campos, Porta Gilda, Marin Maria Lucia C, Bittencourt Paulo Lisboa, Kalil Jorge, Goldberg Anna Carla
Abstract excerpt
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. Characteristic liver-infiltrating immune cells in portal and periportal areas, hypergammaglobulinemia and typical autoantibodies indicate an ongoing autoimmune reaction against liver self antigens, which lead to irreversible cellular damage and ultimately to severe hepatic failure. A significant part of adult, but not pediatric AIH patients,...
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