Article
HLA, gut microbiome and hepatic autoimmunity.
Frontiers in immunology - 1 Jan 2022
Terziroli Beretta-Piccoli Benedetta, Mieli-Vergani Giorgina, Vergani Diego
Abstract excerpt
Genetic susceptibility to autoimmune liver diseases is conferred mainly by polymorphisms of genes encoding for the human leukocyte antigens (HLA). The strongest predisposition to autoimmune hepatitis type 1 (AIH-1) is linked to the allele DRB1*03:01, possession of which is associated with earlier disease onset and more severe course. In populations where this allele is very rare, such as in Asia, and in...
Topics
- Autoimmunity
- Child
- Cholangitis, Sclerosing
- Gastrointestinal Microbiome
- Genetic Predisposition to Disease
- HLA Antigens
- HLA-DRB1 Chains
- Hepatitis, Autoimmune
- Humans