Article
Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.
Gastroenterology - 1 Aug 2014
de Boer Ynto S, van Gerven Nicole M F, Zwiers Antonie, Verwer Bart J, van Hoek Bart, van Erpecum Karel J, Beuers Ulrich, van Buuren Henk R, Drenth Joost P H, den Ouden Jannie W, Verdonk Robert C, Koek Ger H, Brouwer Johannes T, Guichelaar Maureen M J, Vrolijk Jan M, Kraal Georg, Mulder Chris J J, van Nieuwkerk Carin M J, Fischer Janett, Berg Thomas, Stickel Felix, Sarrazin Christoph, Schramm Christoph, Lohse Ansgar W, Weiler-Normann Christina, Lerch Markus M, Nauck Matthias, Völzke Henry, Homuth Georg, Bloemena Elisabeth, Verspaget Hein W, Kumar Vinod, Zhernakova Alexandra, Wijmenga Cisca, Franke Lude, Bouma Gerd
Abstract excerpt
BACKGROUND & AIMS: Autoimmune hepatitis (AIH) is an uncommon autoimmune liver disease of unknown etiology. We used a genome-wide approach to identify genetic variants that predispose individuals to AIH. METHODS: We performed a genome-wide association study of 649 adults in The Netherlands with AIH type 1 and 13,436 controls. Initial associations were further analyzed in an independent replication panel comprising...
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