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Immune sensing of mouse polyomavirus DNA by p204 and cGAS DNA sensors

10 May 2021

Abstract excerpt

The mechanism by which DNA viruses interact with different DNA sensors and their connection with the activation of interferon (IFN) type I pathway are poorly understood. We investigated the roles of protein 204 (p204) and cyclic guanosine-adenosine synthetase (cGAS) sensors during infection with mouse polyomavirus (MPyV). The phosphorylation of IFN regulatory factor 3 (IRF3) and the stimulator of IFN genes...

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PMID: 33969628
DOI: 10.1111/febs.15962

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