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Article

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA

15 Oct 2018

Abstract excerpt

MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic DNA.Cellular trafficking of MITA from the ER to perinuclear microsomes after DNA virus infection is critical for MITA activation and onset of innate antiviral response.Here we found that SNX8 is a component of DNA-triggered induction of downstream effector genes and innate immune response.Snx8 -/-mice infected with the...

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PMID: 30321235
DOI: 10.1371/journal.ppat.1007336

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