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Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

7 Nov 2013

Abstract excerpt

Adenovirus (Ad) infection triggers a cell-specific antiviral response following exposure of viral DNA to the intracellular compartment. A variety of DNA sensors (DAI, AIM2, DDx41, RNA polymerase [Pol] III, and IFI16 [p204]) have been identified in recent years; however, the DNA sensor involved in detection of adenovirus has not been established. Cyclic GMP-AMP synthase (cGAS), a DNA sensor that produces a cyclic...

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PMID: 24198409
DOI: 10.1128/jvi.02702-13

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