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Article

CAP2 in cardiac conduction, sudden cardiac death and eye development.

Scientific reports - 30 Nov 2015

Field Jeffrey, Ye Diana Z, Shinde Manasi, Liu Fang, Schillinger Kurt J, Lu MinMin, Wang Tao, Skettini Michelle, Xiong Yao, Brice Angela K, Chung Daniel C, Patel Vickas V

Abstract excerpt

Sudden cardiac death kills 180,000 to 450,000 Americans annually, predominantly males. A locus that confers a risk for sudden cardiac death, cardiac conduction disease, and a newly described developmental disorder (6p22 syndrome) is located at 6p22. One gene at 6p22 is CAP2, which encodes a cytoskeletal protein that regulates actin dynamics. To determine the role of CAP2 in vivo, we generated knockout (KO) mice....

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Identifiers

PMID: 26616005
DOI: 10.1038/srep17256
PMCID: PMC4663486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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