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Article

BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing.

RNA (New York, N.Y.) - 1 Feb 2013

Chen Po-Han, Lee Chia-I, Weng Yu-Tzu, Tarn Woan-Yuh, Tsao Yeou-Ping, Kuo Ping-Chang, Hsu Pang-Hung, Huang Chu-Wei, Huang Chiun-Sheng, Lee Hsiu-Hsiang, Wu June-Tai, Chen Show-Li

Abstract excerpt

Here, we show that dBCAS2 (CG4980, human Breast Carcinoma Amplified Sequence 2 ortholog) is essential for the viability of Drosophila melanogaster. We find that ubiquitous or tissue-specific depletion of dBCAS2 leads to larval lethality, wing deformities, impaired splicing, and apoptosis. More importantly, overexpression of hBCAS2 rescues these defects. Furthermore, the C-terminal coiled-coil domain of hBCAS2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23249746
DOI: 10.1261/rna.034835.112
PMCID: PMC3543084

Genes

BCAS2
PLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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