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Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes

4 May 2021

Abstract excerpt

Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures of single base substitution (SBS) have been extensively studied in different types of cancer. Copy number alterations are important drivers for the progression of multiple cancer. However, practical tools for studying the signatures of copy number...

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PMID: 33945534
DOI: 10.1371/journal.pgen.1009557

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