Article
Evaluation of polygenic prediction methodology within a reference-standardized framework.
PLoS genetics - 1 May 2021
Pain Oliver, Glanville Kylie P, Hagenaars Saskia P, Selzam Saskia, Fürtjes Anna E, Gaspar Héléna A, Coleman Jonathan R I, Rimfeld Kaili, Breen Gerome, Plomin Robert, Folkersen Lasse, Lewis Cathryn M
Abstract excerpt
The predictive utility of polygenic scores is increasing, and many polygenic scoring methods are available, but it is unclear which method performs best. This study evaluates the predictive utility of polygenic scoring methods within a reference-standardized framework, which uses a common set of variants and reference-based estimates of linkage disequilibrium and allele frequencies to construct scores. Eight...
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