Article
Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2019
Zhang Jin, Sun Wenqiang, Kong Xiangmudong, Zhang Yanhong, Yang Hee Jung, Ren Cong, Jiang Yuqian, Chen Mingyi, Chen Xinbin
Abstract excerpt
p53 is the most frequently mutated gene in human cancers and mutant p53 has a gain of function (GOF) that promotes tumor progression and therapeutic resistance. One of the major GOF activities of mutant p53 is to suppress 2 other p53 family proteins, p63 and p73. However, the molecular basis is not fully understood. Here, we examined whether mutant p53 antagonizes p63/p73-mediated tumor suppression in vivo by...
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