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Reduced purine biosynthesis in humans after their divergence from Neandertals

4 May 2021

Abstract excerpt

We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccinate lyase, which catalyzes two reactions in purine synthesis, occur at lower concentrations in humans. This enzyme...

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PMID: 33942714
DOI: 10.7554/elife.58741

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