Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replication

1 Jan 2022

Abstract excerpt

We aimed at investigating host-virus co-metabolism during SARS-CoV-2 infection. Therefore, we extended comprehensive sex-specific, whole-body organ resolved models of human metabolism with the necessary reactions to replicate SARS-CoV-2 in the lung as well as selected peripheral organs. Using this comprehensive host-virus model, we obtained the following key results: 1. The predicted maximal possible virus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Long-Term Effects of COVID-19
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35874091
DOI: 10.1016/j.csbj.2022.07.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replicationPMID 35874091Read ↗

Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replicationSemantic proximity Read ↗

Inhibiting the reproduction of COVID-19-causing SARS-CoV-2 through perturbations in human cell metabolic networkSemantic proximity Read ↗

Host metabolic reprogramming in response to SARS-Cov-2 infectionSemantic proximity Read ↗

COVID-19: A complex disease with a unique metabolic signature.Semantic proximity Read ↗

Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics AnalysisSemantic proximity Read ↗

Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targetsSemantic proximity Read ↗

Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targetsSemantic proximity Read ↗

Predictive Systems Biology Modeling: Unraveling Host Metabolic Disruptions and Potential Drug Targets in Acute Viral InfectionsSemantic proximity Read ↗

Metabolomics analysis reveals a potential role SARS-CoV-2 viral proteins in the regulation/perturbation of metabolic pathways associated with altered plasma metabolites in COVID-19 patientsSemantic proximity Read ↗

Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral TargetSemantic proximity Read ↗

COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal statusSemantic proximity Read ↗

Role of Multiomics Data to Understand Host–Pathogen Interactions in COVID-19 PathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.