Article

Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replication

2022-04-14

Abstract excerpt

We aimed at investigating host-virus co-metabolism during SARS-CoV-2 infection. Therefore, we extended comprehensive sex-specific, whole-body organ resolved models of human metabolism with the necessary reactions to replicate SARS-CoV-2 in the lung as well as selected peripheral organs. Using this comprehensive host-virus model, we obtained the following key results: 1. The predicted maximal possible virus sheddin...

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Literature Corpus work: 37964c5d-716d-5b6b-8f6e-b6bea878db1d
DOI: 10.1101/2022.04.13.488249

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