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Article

Identification of a Sensitive Human Immunological Target of Aryl Hydrocarbon Receptor Activation: CD5+ Innate-Like B Cells.

Frontiers in immunology - 1 Jan 2021

Blevins Lance K, Zhou Jiajun, Crawford Robert B, Kaminski Norbert E

Abstract excerpt

Xenobiotic-mediated activation of the aryl hydrocarbon receptor (AHR) is immunotoxic in a number of immune cell types, with the B cell being a well-established sensitive target. Recent advances have provided evidence that the B cell repertoire is a heterogeneous population, with subpopulations exhibiting vastly different cellular and functional phenotypes. Recent work from our laboratory identified the T cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33936048
DOI: 10.3389/fimmu.2021.635748
PMCID: PMC8082145

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