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Article

Aryl hydrocarbon receptor-induced activation of the human IGH hs1.2 enhancer: Mutational analysis of putative regulatory binding motifs.

Molecular immunology - 1 Apr 2020

Snyder Andrew D, Ochs Sharon D, Johnson Brooke E, Sulentic Courtney E W

Abstract excerpt

The human hs1.2 enhancer within the Ig heavy chain gene (IGH) is polymorphic and associated with a number of autoimmune diseases. The polymorphic region is characterized by tandem repeats of an ∼53-bp invariant sequence containing possible binding sites for several transcription factors. Our previous studies suggest the human hs1.2 enhancer is sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Genes, Immunoglobulin Heavy Chain

Share to Mutagenesis, Site-Directed

Share to Polychlorinated Dibenzodioxins

Share to Receptors, Aryl Hydrocarbon

Share to Transcriptional Activation

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Identifiers

PMID: 32146146
DOI: 10.1016/j.molimm.2020.02.002
PMCID: PMC7103136

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