Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of aryl hydrocarbon receptor polymorphisms on TCDD-mediated CYP1B1 induction and IgM suppression by human B cells.

Toxicology and applied pharmacology - 15 Oct 2016

Kovalova Natalia, Manzan Maria, Crawford Robert, Kaminski Norbert

Abstract excerpt

Previous studies have demonstrated that most of the intraspecies variation in sensitivity to the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), including suppression of antibody responses, in murine models is due to single nucleotide polymorphisms (SNPs) within the aryl hydrocarbon receptor (AhR) gene. The underlying reason for variation in sensitivity to TCDD-induced suppression of IgM responses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Cytochrome P-450 CYP1A2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1B1

Share to Enzyme Induction

Share to Immunoglobulin M

Share to Polychlorinated Dibenzodioxins

Share to Rats, Sprague-Dawley

Share to Receptors, Aryl Hydrocarbon

Source

Open in PubMed Open full text

Identifiers

PMID: 27535091
DOI: 10.1016/j.taap.2016.08.011
PMCID: PMC5035641

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of aryl hydrocarbon receptor polymorphisms on TCDD-mediated CYP1B1 induction and IgM suppression by human B cells.PMID 27535091Read ↗

Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines.Semantic proximity Read ↗

Identification of a Sensitive Human Immunological Target of Aryl Hydrocarbon Receptor Activation: CD5+ Innate-Like B Cells.Semantic proximity Read ↗

Polymorphisms in the human AH receptor.Semantic proximity Read ↗

The human AHR: identification of single nucleotide polymorphisms from six ethnic populations.Semantic proximity Read ↗

Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.Semantic proximity Read ↗

The aryl hydrocarbon receptor: Regulation of hematopoiesis and involvement in the progression of blood diseasesSemantic proximity Read ↗

Aryl hydrocarbon receptor-induced activation of the human IGH hs1.2 enhancer: Mutational analysis of putative regulatory binding motifs.Semantic proximity Read ↗

Aryl Hydrocarbon Receptor-Mediated Induction of EBV Reactivation as a Risk Factor for Sjögren’s SyndromeSemantic proximity Read ↗

Relationships among CYP2B6 genetic variants and serum levels of multiple polychlorinated biphenyls and hydroxylated metabolites in a Japanese population.Semantic proximity Read ↗

Novel role of hnRNP-A2/B1 in modulating aryl hydrocarbon receptor ligand sensitivity.Semantic proximity Read ↗

Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cellsSemantic proximity Read ↗

AHR gene-dioxin interactions and birthweight in the Seveso Second Generation Health Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.