Article
Establishment of CYP2D6 reference samples by multiple validated genotyping platforms.
The pharmacogenomics journal - 1 Dec 2014
Fang H, Liu X, Ramírez J, Choudhury N, Kubo M, Im H K, Konkashbaev A, Cox N J, Ratain M J, Nakamura Y, O'Donnell P H
Abstract excerpt
Cytochrome P450 2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6)), a highly polymorphic drug-metabolizing enzyme, is involved in the metabolism of one-quarter of the most commonly prescribed medications. Here we have applied multiple genotyping methods and Sanger sequencing to assign precise and reproducible CYP2D6 genotypes, including copy numbers, for 48 HapMap samples. Furthermore, by...
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