Article
[Molecular Mechanisms of HIV-1 Genetic Diversity].
Molekuliarnaia biologiia - 1 Jan 2000
Sosin D V, Tchurikov N A
Abstract excerpt
High genetic diversity of HIV-1 is the main factor behind the fact that HIV infection is widespread and difficult to treat. Although a limited number (or only one) of virus particles enters the blood upon infection, the particles are replicated in infected cells and rapidly produce new genetic variants that are resistant to the host immune system and antiretroviral drugs. This circumstance hampers the development...
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