Article
Genetic Variability of Long Terminal Repeat Region between HIV-2 Groups Impacts Transcriptional Activity.
Journal of virology - 17 Mar 2020
Le Hingrat Quentin, Visseaux Benoit, Bertine Mélanie, Chauveau Lise, Schwartz Olivier, Collin Fidéline, Damond Florence, Matheron Sophie, Descamps Diane, Charpentier Charlotte
Abstract excerpt
The HIV-2 long terminal repeat (LTR) region contains several transcription factor (TF) binding sites. Efficient LTR transactivation by cellular TF and viral proteins is crucial for HIV-2 reactivation and viral production. Proviral LTRs from 66 antiretroviral-naive HIV-2-infected patients included in the French ANRS HIV-2 CO5 Cohort were sequenced. High genetic variability within the HIV-2 LTR was observed,...
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