Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs

11 Jun 2012

Abstract excerpt

OBJECTIVES: Precise characterization of viruses present in reservoirs in long-term pretreated patients will be a major issue to consider in the context of viral eradication. We assessed the frequency of defective viruses present in cellular reservoirs. METHODS: Peripheral blood mononuclear cells (PBMCs) and rectal biopsy samples were compared between five patients on successful long-term highly active...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV-related health complications and treatments
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22687892
DOI: 10.1093/jac/dks219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirsPMID 22687892Read ↗

Presence of HIV-1 G-to-A mutations linked to APOBEC editing is more prevalent in non-B HIV-1 subtypes and is associated with lower HIV-1 reservoir.Semantic proximity Read ↗

Establishment and stability of the latent HIV-1 DNA reservoir.Semantic proximity Read ↗

Patients on HAART often have an excess of unintegrated HIV DNA: Implications for monitoring reservoirsSemantic proximity Read ↗

Extremely High Mutation Rate of HIV-1 In VivoSemantic proximity Read ↗

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV ControlSemantic proximity Read ↗

Full-length title: Dramatic HIV DNA degradation associated with spontaneous HIV suppression and disease-free outcome in a young seropositive woman following her infection.Semantic proximity Read ↗

Dramatic HIV DNA degradation associated with spontaneous HIV suppression and disease-free outcome in a young seropositive woman following her infectionSemantic proximity Read ↗

Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapySemantic proximity Read ↗

A higher CD4/CD8 ratio correlates with an ultralow cell-associated HIV-1 DNA level in chronically infected patients on antiretroviral therapy: a case control studySemantic proximity Read ↗

Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment.Semantic proximity Read ↗

The latent HIV reservoir: current advances in genetic sequencing approachesSemantic proximity Read ↗

CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 ProvirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.