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Article

Acute methotrexate-induced encephalopathy--causal relation to homozygous allelic state for MTR c.2756A>G (D919G)?

Journal of chemotherapy (Florence, Italy) - 1 Aug 2007

Linnebank M, Malessa S, Moskau S, Semmler A, Pels H, Klockgether T, Schlegel U

Abstract excerpt

Methotrexate (MTX) is widely used in the treatment of hematological diseases. The typical side-effects of high-dose MTX chemotherapy on the CNS range from asymptomatic white matter changes to severe CNS demyelination. MTX neuro - toxicity has been described to be associated with homocysteine and...

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Source

Identifiers

PMID: 17855192
DOI: 10.1179/joc.2007.19.4.455

Genes

MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17855192-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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