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EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.

Veterinary pathology - 1 Jul 2021

Cho Seung-Hee, Seung Byung-Joon, Kim Soo-Hyeon, Bae Min-Kyung, Lim Ha-Young, Sur Jung-Hyang

Abstract excerpt

Epidermal growth factor receptor (EGFR) is overexpressed in many human colorectal cancers and anti-EGFR agents are employed as immunotherapies. However, KRAS, EGFR, and BRAF gene mutations can influence the activity of the anti-EGFR agents. We evaluated EGFR expression at protein and mRNA levels in canine intestinal adenocarcinomas using immunohistochemistry (IHC) and RNA in situ hybridization (RNA-ISH). We also...

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PMID: 33926328
DOI: 10.1177/03009858211009778

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