Article
Overexpression and Mutation of p53 Exons 4-8 in Canine Intestinal Adenocarcinoma.
Journal of comparative pathology - 1 Feb 2020
Cho S H, Seung B J, Kim S H, Lim H Y, Sur J H
Abstract excerpt
p53 is mutated and overexpressed during malignant transformation, including in human colorectal cancer. This study investigated the overexpression of p53 protein and mutations in the p53 gene in canine intestinal neoplasia (CIN). Immunohistochemical analysis of p53 was carried out in formalin-fixed and paraffin wax-embedded (FFPE) sections of intestinal tissues from 35 dogs with CIN by the standard...
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