Article
Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test.
Molecular cancer research : MCR - 1 Jun 2015
Decker Brennan, Parker Heidi G, Dhawan Deepika, Kwon Erika M, Karlins Eric, Davis Brian W, Ramos-Vara José A, Bonney Patty L, McNiel Elizabeth A, Knapp Deborah W, Ostrander Elaine A
Abstract excerpt
UNLABELLED: Targeted cancer therapies offer great clinical promise, but treatment resistance is common, and basic research aimed at overcoming this challenge is limited by reduced genomic and biologic complexity in artificially induced rodent tumors compared with their human counterparts. Animal models that more faithfully recapitulate genotype-specific human pathology could improve the predictive value of these...
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