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Article

Sequence analysis of RAS and RAF mutation hot spots in canine carcinoma.

Veterinary and comparative oncology - 1 Dec 2017

Mochizuki H, Breen M

Abstract excerpt

Recent discovery of the BRAF V595E mutation in a variety of canine cancers indicates that mutant BRAF may represent a novel therapeutic target. Presence of RAS mutations is associated with poor tumour response to BRAF inhibition but has not been investigated in BRAF-mutated canine cancers. The aim of this study was to evaluate the mutational status of three RAS genes (HRAS, KRAS and NRAS) in four types of canine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27714944
DOI: 10.1111/vco.12275

Genes

BRAF
HRAS
KRAS
NRAS

Variants

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