Article

Identification of frequent activating <i>HER2</i> mutations in primary canine pulmonary adenocarcinoma

2019-01-25

Abstract excerpt

<h4>ABSTRACT</h4> Naturally occurring primary canine lung cancers are aggressive malignancies that are increasingly common in pet dogs. They share clinicopathologic features with human lung cancers in never-smokers, but their genetic underpinnings are unknown. Through multi-platform sequencing of 88 primary canine lung tumors or cell lines, we discovered somatic, coding HER2 (ERRB2) point mutations in 38% of can...

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Literature Corpus work: 319b2723-7287-57c9-8566-e8df7ae77ebb
DOI: 10.1101/528182

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