Article
Detection of MYD88 L265P mutation by real-time allele-specific oligonucleotide polymerase chain reaction.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000
Jiménez Cristina, Chillón María Del Carmen, Balanzategui Ana, Puig Noemí, Sebastián Elena, Alcoceba Miguel, Sarasquete María E, Conde Isabel P, Corral Rocío, Marín Luis A, Paiva Bruno, Ruano Montserrat, Antón Alicia, Maldonado Rebeca, San Miguel Jesús F, González Marcos, García-Sanz Ramón
Abstract excerpt
MYD88 L265P mutation has been reported in ∼90% of Waldenström's Macroglobulinemia (WM) patients and immunoglobulin M (IgM) monoclonal gammopathies of uncertain significance (MGUS), as well as in some cases of lymphoma and chronic lymphocytic leukemia. The present study aimed to develop a real-time allele-specific oligonucleotide PCR (ASO-RQ-PCR) to detect the MYD88 L265P mutation. We first evaluated the...
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