Article

Treatment with IFB-088 improves neuropathy in CMT1A and CMT1B mice

2021-10-18

Abstract excerpt

Charcot Marie Tooth diseases type 1A (CMT1A), caused by duplication of Peripheral Myelin Protein 22 ( PMP22 ) gene, and CMT1B, caused by mutations in myelin protein zero ( MPZ ) gene are the two most common forms of demyelinating CMT (CMT1) and no treatments are available for either. Prior studies of the Mpz Ser63del mouse model of CMT1B have demonstrated that protein misfolding, endoplasmic reticulum (ER) rete...

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Literature Corpus work: 221fc92f-9c58-50ee-a1f2-9df06fc72d55
DOI: 10.1101/2021.10.18.464779

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