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Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.

Cell reports - 21 Dec 2021

Mannar Dhiraj, Saville James W, Zhu Xing, Srivastava Shanti S, Berezuk Alison M, Zhou Steven, Tuttle Katharine S, Kim Andrew, Li Wei, Dimitrov Dimiter S, Subramaniam Sriram

Abstract excerpt

The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Beta (B.1.351) and Gamma (P.1) variants of concern (VoCs) include a key mutation (N501Y) found in the Alpha (B.1.1.7) variant that enhances affinity of the spike protein for its receptor, angiotensin-converting enzyme 2 (ACE2). Additional mutations are found in these variants at residues 417 and 484 that appear to promote antibody...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34914928
DOI: 10.1016/j.celrep.2021.110156
PMCID: PMC8642162

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