Article

Interactome mapping reveals a role for LRP10 in autophagy and NDFIP1-mediated α-synuclein secretion

2023-11-29

Abstract excerpt

Variants in the LRP10 gene have been found in a spectrum of neurodegenerative disorders, including Lewy body diseases (LBDs). In brains of LBD patients, LRP10 is found in neuronal α-synuclein-containing Lewy bodies, astrocytes, and vasculature, but not in inclusion-free neurons. Furthermore, recent work suggests that LRP10 is involved in α-synuclein processing and transmission, which is disrupted by the LBD-assoc...

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Literature Corpus work: 1080d9ff-9255-58ba-b8d5-c5095d93b1b3
DOI: 10.1101/2023.11.28.569009

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