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Article

Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination

7 Oct 2014

Abstract excerpt

The signal-responsive E3 ubiquitin ligase pellino 1 (PELI1) regulates TLR and T cell receptor (TCR) signaling and contributes to the maintenance of autoimmunity; however, little is known about the consequence of mutations that result in upregulation of PELI1. Here, we developed transgenic mice that constitutively express human PELI1 and determined that these mice have a shorter lifespan due to tumor formation....

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PMID: 25295537
DOI: 10.1172/jci75667

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