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B cell development: transcriptional regulation and immunological mechanisms in homeostasis

8 Aug 2025

Abstract excerpt

B lymphocytes are essential elements of the adaptive immune response, performing critical functions such as antigen presentation, cytokine secretion, and antibody production. Their development follows a tightly regulated progression from hematopoietic stem cells to differentiated plasma or memory cells, orchestraeted by key transcriptional factors including PU.1, Ikaros, E2A, Pax-5, and BCL6. These factors govern...

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PMID: 40861439
DOI: 10.3389/fimmu.2025.1593338

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