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Article

NLRP6 in host defense and intestinal inflammation

1 Apr 2021

Abstract excerpt

NLRP6 is a member of the NLR (nucleotide-oligomerization domain-like receptor) family of proteins that recognize pathogen-derived factors and damage-associated molecular patterns in the cytosol. The function of NLRP6 has been attributed to the maintenance of epithelial integrity and host defense against microbial infections. Under some physiological conditions, NLRP6 forms a complex with ASC and caspase-1 or...

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PMID: 33910012
DOI: 10.1016/j.celrep.2021.109043

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