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Chromosome Missegregation in Single Human Oocytes Is Related to the Age and Gene Expression Profile

12 Mar 2020

Abstract excerpt

The growing trend for women to postpone childbearing has resulted in a dramatic increase in the incidence of aneuploid pregnancies. Despite the importance to human reproductive health, the events precipitating female age-related meiotic errors are poorly understood. To gain new insight into the molecular basis of age-related chromosome missegregation in human oocytes, we combined the transcriptome profiles of...

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PMID: 32178390
DOI: 10.3390/ijms21061934

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