Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia.

doi:10.1038/s41431-021-00885-y

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Article

Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia.

European journal of human genetics : EJHG - 1 May 2022

Restuadi Restuadi, Garton Fleur C, Benyamin Beben, Lin Tian, Williams Kelly L, Vinkhuyzen Anna, van Rheenen Wouter, Zhu Zhihong, Laing Nigel G, Mather Karen A, Sachdev Perminder S, Ngo Shyuan T, Steyn Frederik J, Wallace Leanne, Henders Anjali K, Visscher Peter M, Needham Merrilee, Mathers Susan, Nicholson Garth, Rowe Dominic B, Henderson Robert D, McCombe Pamela A, Pamphlett Roger, Blair Ian P, Wray Naomi R, McRae Allan F

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is recognised to be a complex neurodegenerative disease involving both genetic and non-genetic risk factors. The underlying causes and risk factors for the majority of cases remain unknown; however, ever-larger genetic data studies and methodologies promise an enhanced understanding. Recent analyses using published summary statistics from the largest ALS genome-wide association...

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PMID: 33907316
DOI: 10.1038/s41431-021-00885-y
PMCID: PMC9090723

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