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Article

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.

Nature communications - 21 Mar 2017

McLaughlin Russell L, Schijven Dick, van Rheenen Wouter, van Eijk Kristel R, O'Brien Margaret, Kahn René S, Ophoff Roel A, Goris An, Bradley Daniel G, Al-Chalabi Ammar, van den Berg Leonard H, Luykx Jurjen J, Hardiman Orla, Veldink Jan H

Abstract excerpt

We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the...

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PMID: 28322246
DOI: 10.1038/ncomms14774
PMCID: PMC5364411

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