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Article

Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank.

Journal of neurology - 1 Oct 2024

Jin Weijia, Boss Jonathan, Bakulski Kelly M, Goutman Stephen A, Feldman Eva L, Fritsche Lars G, Mukherjee Bhramar

Abstract excerpt

BACKGROUND AND OBJECTIVES: Amyotrophic lateral sclerosis (ALS) causes profound impairments in neurological function, and a cure for this devastating disease remains elusive. This study aimed to identify pre-disposing genetic, phenotypic, and exposure-related factors for amyotrophic lateral sclerosis using multi-modal data and assess their joint predictive potential. METHODS: Utilizing data from the UK (United...

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PMID: 39249108
DOI: 10.1007/s00415-024-12644-2

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