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Article

MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.

Gastroenterology - 1 Aug 2021

Lu Ying, Li Yangyang, Liu Qi, Tian Na, Du Peng, Zhu Fangming, Han Yichao, Liu Xinnan, Liu Xisheng, Peng Xiao, Wang Xiaoxia, Wu Yuchen, Tong Lingfeng, Li Yakui, Zhu Yemin, Wu Lifang, Zhang Ping, Xu Ye, Chen Hanbei, Li Bin, Tong Xuemei

Abstract excerpt

BACKGROUND & AIMS: The metabolic features and function of intratumoral regulatory T cells (Tregs) are ambiguous in colorectal cancer. Tumor-infiltrating Tregs are reprogrammed to exhibit high glucose-depleting properties and adapt to the glucose-restricted microenvironment. The glucose-responsive transcription factor MondoA is highly expressed in Tregs. However, the role of MondoA in colorectal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33901495
DOI: 10.1053/j.gastro.2021.04.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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