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Article

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults.

PLoS genetics - 1 Apr 2021

Li Binglan, Veturi Yogasudha, Verma Anurag, Bradford Yuki, Daar Eric S, Gulick Roy M, Riddler Sharon A, Robbins Gregory K, Lennox Jeffrey L, Haas David W, Ritchie Marylyn D

Abstract excerpt

As a type of relatively new methodology, the transcriptome-wide association study (TWAS) has gained interest due to capacity for gene-level association testing. However, the development of TWAS has outpaced statistical evaluation of TWAS gene prioritization performance. Current TWAS methods vary in underlying biological assumptions about tissue specificity of transcriptional regulatory mechanisms. In a previous...

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PMID: 33901188
DOI: 10.1371/journal.pgen.1009464
PMCID: PMC8102009

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