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Article

Causal associations of serum matrix metalloproteinase-8 level with ischaemic stroke and ischaemic stroke subtypes: a Mendelian randomization study.

European journal of neurology - 1 Aug 2021

Jia Yiming, Guo Daoxia, Zhang Kaixin, Yang Pinni, Zang Yuhan, Sun Lulu, Wang Yu, Liu Fanghua, Shi Mengyao, Zhang Yonghong, Zhu Zhengbao

Abstract excerpt

BACKGROUND AND PURPOSE: Elevated serum matrix metalloproteinase-8 (MMP-8) concentrations are associated with high risk of vascular disease, but the causality remains unclear. A two-sample Mendelian randomization (MR) study was performed to examine the causal effect of serum MMP-8 concentrations on the risk of ischaemic stroke, ischaemic stroke subtypes and coronary artery disease. METHODS: Ten independent...

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Brain Ischemia
Genome-Wide Association Study
Ischemic Stroke
Matrix Metalloproteinase 8
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 33894037
DOI: 10.1111/ene.14878

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