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Article

Mendelian randomization study of lithocholate sulfate mediating the effect of MMP-1 on ischemic stroke.

Medicine - 13 Mar 2026

Wei Yuyu, Tian Jialong, Pang Xiaojun, Chen Huai, Jin Xuhong, Zhang Zibin

Abstract excerpt

This study aimed to investigate the potential causal relationship between the inflammatory factor matrix metalloproteinase-1 (MMP-1) and ischemic stroke (IS) using Mendelian randomization (MR), and to examine whether the gut microbiota-derived metabolite lithocholate sulfate (LSL) mediates this association. We performed a 2-sample MR analysis to assess the causal effect of genetically predicted MMP-1 levels...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Ischemic Stroke
Matrix Metalloproteinase 1
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 41824852
DOI: 10.1097/MD.0000000000048010
PMCID: PMC12991698

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