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Article

CD146 extracellular vesicles accumulate at atherosclerotic lesions, reducing inflammation and atheroma burden.

Atherosclerosis - 1 Jul 2026

Dubrou Cléa, Blin Muriel G, Fallague Karim, Bachelier Richard, Simoncini Stéphanie, Chareyre Corinne, Robert Stéphane, Bertaud Alexandrine, Lacroix Romaric, Dignat-George Françoise, Bardin Nathalie, Blot-Chabaud Marcel, Leroyer Aurélie S

Abstract excerpt

Atherosclerosis remains the most important cause of death worldwide despite an extensive therapeutic arsenal. We previously showed that CD146, an adhesion molecule expressed by endothelial cells, is harbored by macrophages in atherosclerotic plaque and allows to reduce CCL5 and subsequent inflammation. As extracellular vesicles may serve as potential clinical delivery devices, we hypothesized that CD146...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42251801
DOI: 10.1016/j.atherosclerosis.2026.120797

Genes

CCL5
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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