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Article

Association of Genetic Variants for Plasma LRG1 With Rapid Decline in Kidney Function in Patients With Type 2 Diabetes.

The Journal of clinical endocrinology and metabolism - 13 Jul 2021

Gurung Resham Lal, Dorajoo Rajkumar, M Yiamunaa, Liu Jian-Jun, Pek Sharon Li Ting, Wang Jiexun, Wang Ling, Sim Xueling, Liu Sylvia, Shao Yi-Ming, Ang Keven, Subramaniam Tavintharan, Tang Wern Ee, Sum Chee Fang, Liu Jian-Jun, Lim Su Chi

Abstract excerpt

CONTEXT: Elevated levels of plasma leucine-rich α-2-glycoprotein 1 (LRG1), a component of transforming growth factor beta signaling, are associated with development and progression of chronic kidney disease in patients with type 2 diabetes (T2D). However, whether this relationship is causal is uncertain. OBJECTIVES: To identify genetic variants associated with plasma LRG1 levels and determine whether genetically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33889958
DOI: 10.1210/clinem/dgab268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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