Article
GCKR and GCK polymorphisms are associated with increased risk of end-stage kidney disease in Chinese patients with type 2 diabetes: The Hong Kong Diabetes Register (1995-2019).
Diabetes research and clinical practice - 1 Nov 2022
Wang Ke, Shi Mai, Yang Aimin, Fan Baoqi, Tam Claudia H T, Lau Eric, Luk Andrea O Y, Kong Alice P S, Ma Ronald C W, Chan Juliana C N, Chow Elaine
Abstract excerpt
AIMS: Glucokinase (GCK) and glucokinase regulatory protein (GKRP) regulate glucose and lipid metabolism. We investigated the associations of GCKR and GCK polymorphisms with kidney outcomes. METHODS: Analyses were performed in a prospective cohort who were enrolled in the Hong Kong Diabetes Register between 1995 and 2017. The associations of GCKR rs1260326 and GCK rs1799884 polymorphisms with incident end-stage...
Read the complete abstract on PubMed