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Article

A GREM1 gene variant associates with diabetic nephropathy.

Journal of the American Society of Nephrology : JASN - 1 May 2010

McKnight Amy Jayne, Patterson Christopher C, Pettigrew Kerry A, Savage David A, Kilner Jill, Murphy Madeline, Sadlier Denise, Maxwell Alexander P

Abstract excerpt

Gremlin, a cell growth and differentiation factor, promotes the development of diabetic nephropathy in animal models, but whether GREM1 gene variants associate with diabetic nephropathy is unknown. We comprehensively screened the 5' upstream region (including the predicted promoter), all exons, intron-exon boundaries, complete untranslated regions, and the 3' region downstream of the GREM1 gene. We identified 31...

Topics

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Amino Acid Sequence
Base Sequence
Case-Control Studies
Diabetic Nephropathies
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intercellular Signaling Peptides and Proteins

Linkage Disequilibrium

Sequence Alignment

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Identifiers

PMID: 20150533
DOI: 10.1681/ASN.2009070773
PMCID: PMC2865734

Genes

GREM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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