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Article

T cell self-reactivity during thymic development dictates the timing of positive selection.

eLife - 22 Apr 2021

Lutes Lydia K, Steier Zoë, McIntyre Laura L, Pandey Shraddha, Kaminski James, Hoover Ashley R, Ariotti Silvia, Streets Aaron, Yosef Nir, Robey Ellen A

Abstract excerpt

Functional tuning of T cells based on their degree of self-reactivity is established during positive selection in the thymus, although how positive selection differs for thymocytes with relatively low versus high self-reactivity is unclear. In addition, preselection thymocytes are highly sensitive to low-affinity ligands, but the mechanism underlying their enhanced T cell receptor (TCR) sensitivity is not fully...

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Share to Cell Lineage
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channels

Share to Receptors, Antigen, T-Cell

Share to Self Tolerance

Share to Thymocytes

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Source

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Identifiers

PMID: 33884954
DOI: 10.7554/eLife.65435
PMCID: PMC8116051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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