Article

Sparse, random sampling is sufficient for central tolerance

2025-12-12

Abstract excerpt

Negative selection in the thymus limits autoimmunity by eliminating T cells that react strongly to self. Individual T cells, however, are only exposed to a small fraction of all self peptides during their “training” in the thymus, and it is puzzling how tolerance can be generalized to the remaining “test” self peptides across peripheral tissues in the body. Using a machine learning perspective, we show that such g...

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Literature Corpus work: 3ecbfea7-3ae4-5869-bb4d-7848873a6add
DOI: 10.64898/2025.12.09.693230

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