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Article

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.

Nature immunology - 1 Apr 2001

Jordan M S, Boesteanu A, Reed A J, Petrone A L, Holenbeck A E, Lerman M A, Naji A, Caton A J

Abstract excerpt

Despite accumulating evidence that regulatory T cells play a crucial role in preventing autoimmunity, the processes underlying their generation during immune repertoire formation are unknown. We show here that interactions with a single self-peptide can induce thymocytes that bear an autoreactive...

Read the complete abstract on PubMed

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Share to Autoantigens
Share to CD4-Positive T-Lymphocytes
Share to Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Source

Identifiers

PMID: 11276200
DOI: 10.1038/86302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11276200-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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